曹修岭，博士，副教授，林业硕士生导师

研究方向

利用高通量表型组平台开展细胞衰老及抗衰老活性成分机理的研究

学习与工作经历

2017.09-至今 金沙集团1862成色 金沙集团1862成色 专任教师

2015.08-2017.09 瑞典哥德堡大学 化学与分子生物学系 博士后

2009.09-2015.07 中国农业大学 生物学院 硕博连读

教学工作

研究生：《高级生物化学》《生物学材料与研究方法》《植物细胞生物学技术与方法》

本科生：《衰老的秘密》《高级微生物研究法》

科研项目

1.国家自然科学基金青年项目, 32000387,酵母衰老过程中Yhb1生理性聚集对α-synuclein和synphilin-1细胞毒性的影响及其机制研究, 2021.01-2023.12, 24万,主持

2.浙江省自然科学基金青年项目, LQ19C070001, synphilin-1蛋白聚集体在酵母中与线粒体互作的原位结构及其对线粒体功能影响的分析, 2019.01-2021.12, 9万,主持

3.国家自然科学基金青年项目, 31800163, JB6细胞壁的三维结构、组成成分及其在JB6适应碳酸盐胁迫中的作用分析, 2019.01-2021.12, 27万,参与

论文与专著

1、Xuejiao Jin(co-first), Min Zhou(co-first), Shuxin Chen, Danqi Li,Xiuling Cao^*, Beidong Liu^*, Effects of pH alterations on stress- and aging-induced protein phase separation,Cellular and Molecular Life Sciences, 2022, 79(7):380

2、Xiuling Cao(co-first)^*, Tingting An(co-first), Wenhao Fu, Jie Zhang, Huihui Zhao, Danqi Li, Xuejiao Jin^*, Beidong Liu^*, Genome-wide identification of cellular pathways and key genes that respond to sodium bicarbonate stress inSaccharomyces cerevisiae,Frontiers in Microbiology, 2022, 13:831973

3、Wenhao Fu(co-first),Xiuling Cao(co-first)^*, Tingting An, Huihui Zhao, Jie Zhang, Danqi Li, Xuejiao Jin^*, Beidong Liu^*, Genome-wide identification of resistance genes and transcriptome regulation in yeast to accommodate ammonium toxicity,BMC Genomics, 2022, 23(1):514

4、Xuejiao Jin(co-first), Huihui Zhao(co-first), Min Zhou, Jie Zhang, Tingting An, Wenhao Fu, Danqi Li,Xiuling Cao^*, Beidong Liu^*, Retromer complex and PI3K complex II-related genes mediate the yeast (Saccharomyces cerevisiae) sodium metabisulfite resistance response,Cells, 2021, 10(12):3512

5、Xuejiao Jin,Xiuling Cao (co-first), Shenkui Liu*, and Beidong Liu*, Functional roles of Poly(ADP-Ribose) in stress granule formation and dynamics,Frontiers in Cell and Developmental Biology, 2021, 9: 671780.

6、Xuejiao Jin, Jie Zhang (co-first), Tingting An (co-first), Huihui Zhao, Wenhao Fu, Danqi Li, Shenkui Liu,Xiuling Cao*, and Beidong Liu*, A genome-wide screen inSaccharomyces cerevisiaereveals a critical role for oxidative phosphorylation in cellular tolerance to lithium hexafluorophosphate,Cells, 2021, 10(4): 888.

7、Xiuling Cao, Xuejiao Jin, and Beidong Liu*, Genome-wide imaging-based phenomic screening using yeast (Saccharomyces cerevisiae) strain collections,Methods in Molecular Biology, 2021, 2196:85-95.

8、Xiuling Cao, Xuejiao Jin (co-first), Beidong Liu*, The involvement of stress granules in aging and aging associated diseases,Aging Cell, 2020, 00: e13136.

9、Xiaoling Wang,Xiuling Cao (co-first), Min Liu, Ruiqi Zhang, Xin Zhang, Zongyu Gao, Xiaofei Zhao, Kai Xu, Dawei Li, Yongliang Zhang*, Hsc70-2 is required forBeet black scorch virusinfection through interaction with replication and capsid proteins,Scientific Reports, 2018, 8(1): 4526.

10、Junsheng Yang, Xinxin Hao,Xiuling Cao, Beidong Liu*, Thomas Nyström*, Spatial sequestration and detoxification of Huntingtin by the ribosome quality control complex.eLife, 2016, 5: e11792.

11、Xiuling Cao, Xuejiao Jin, Xiaofeng Zhang, Ying Li, Chunyan Wang, Xianbing Wang, Jian Hong, Xiaofeng Wang, Dawei Li, Yongliang Zhang*, Morphogenesis of endoplasmic reticulum membrane-invaginated vesicles duringBeet Black Scorch Virusinfection: role of auxiliary replication protein and new implications of three-dimensional architecture,Journal of Virology, 2015, 89(12): 6184-6195.

联系方式

通讯地址:浙江省杭州市临安区武肃街666号国重楼429

邮 编: 311300

邮 箱: cxiuling@zafu.edu.cn